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Guicciardi ME, Gores GJ

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6 Technological Moats: Developing oral small molecules and high-potency poly-agonists to switch the patient population away from aging peptide assets before generic entry

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models like GPT-4we really dont know how they work

For most women, the clinical conversation ends at oral contraceptives for cycle regulation, metformin for insulin resistance, and the diffuse instruction to "lose weight." What it rarely includes is any serious engagement with the signaling dysfunctions that make PCOS resistant to those blunt interventions in the first place